We live in a world where regulations continue to get tighter by the FDA which makes cutting edge regenerative medicine evolve at an elevated pace. With the FDA changing their view on peptide therapy in 2023, the medical community was motivated to continue to offer regenerative peptides since they fix the actual issues in the body, not just mask the symptoms.
BPC-157 was on the list of guidelines of medications that were to be stopped being compounded. Scientists & pharmacists had already had a new version of BPC-157 in development called Pentadeca Arginate (PDA). PDA has a very similar molecular structure to BPC-157. At All U Health, we are committed to offer the latest peptides in order to continue to help you feel & look your best!
The main purposes of Pentadeca Arginate are to promote & accelerate the healing of many different wounds, including tendon-to-bone healing & superior healing of damaged ligaments, regeneration, reduce pain & improve recovery times. It’s powerful regenerative & anti-inflammatory properties helps to speed up soft tissue repair & promote collagen synthesis for wounds, tendon, ligament, muscle, scar tissue, sports, & athletic injuries. This peptide is taken by subcutaneous injections.
Drawing from the properties of BPC-157, which is derived from a protein in human gastric juice, PDA shows promise in accelerating the healing of various tissues, muscle recovery, & pain reduction. It is composed of 15 amino acids, is a partial sequence of body protection compound that is discovered in and isolated from the human gastric juice. It works in response to tendon and ligament injury by accelerating the healing. This is done by increasing type 1 collagen in these tissues which promotes healing & not blocking the nerve ending. This stimulation is critical to long term healing & not just short-term pain management. When the body increases blood flow to the damaged tissue from vascular regeneration, it will help with long term tissue health. As a result, PDA has a high regenerative & healing ability found to function not only for plethora of soft tissues, muscles, & ligaments, but also for inner organs, skin, nervous system, & treating problems as ulcers, Crohn’s disease, & leaky gut problems. It also has analgesic effects & enhances reticulin & collagen production, angiogenesis, along with stimulation of macrophage, & fibroblast infiltration. Furthermore, research studies have also shown its ability to assist in faster healing of chemical skin burns by increasing blood flow to damaged tissues.
Pentadeca Arginate, represents a significant breakthrough in the field of longevity & wellness. This peptide, known for its exceptional healing & regenerative properties, is part of a comprehensive portfolio aimed at combatting the effects of aging & enhancing overall vitality. It has also been shown to protect organs & to prevent ulcers of the stomach & may aid in decreasing pain in damaged areas. Those who suffer from discomfort due to muscle sprains, tears, & damage may benefit from treatment with PDA. It can also help aid skin burns to heal at a faster rate & increase blood flow to damaged tissues.
Key areas that Pentadeca Arginate may impact:
- Wound Healing: According to the cDNA microarray analysis, PDA increased the expression of growth hormone receptors in tendon fibroblasts. These are the cells, which are an integral part of wound healing & are responsible for storing extracellular matrix proteins such as collagen, fibrin, elastin, etc. Pentadeca Arginate has been shown to affect fibroblast proliferation in a dose-dependent, time-dependent manner, & the cells both proliferate & migrate faster as a result.
- Vascular Growth and Vessel Collateralization: Vascular growth plays an important role in growth of tissues & regeneration in the body, & refers to the process by which blood vessels develop & grow. Various physiological & pathological states, such as wound healing or regeneration after damage can be connected with these processes. Studies indicated, that PDA is a strong angiogenic factor that stimulates the growth rate & proliferation of endothelial cells. Part of the mechanism by which Pentadeca Arginate promotes vascular endothelial cell growth occurs through stimulation of the cell surface receptor VEGFR2, which is active in the nitric oxide signaling pathway. In vitro study using human vascular endothelial cells further confirmed the increased mRNA and protein expressions of VEGFR2 but not VEGF-A.
- Tendon Healing: Tendon injuries are very common, their healing is often difficult, and very slow. In addition, the healed tendons are usually weaker than before injury. New therapeutical treatment is therefore important to develop. PDA accelerates fibroblasts recruitment & blood supply into injured tissues. It also promotes wound regeneration in tendons, ligaments, muscles, & bones. Furthermore, PDA is a potent stimulator of F-actin production in fibroblasts.
- Anti-inflammatory Effects: With any injury, inflammation results from the body’s response to the trauma. The inflammatory response is a signal the body is responding & has started the repair process. The issue is the inflammation can inhibit the actual process of healing if it is too much. PDA regulates the inflammation by assisting the body to repair the injury in a faster pace which will lead to overall reduction of inflammation.
Key Benefits of PDA:
- Tendon healing
- Decrease pain & inflammation
- Increase collagen synthesis
- Quicker recovery times post-injury
- Wound & bone healing
- Intestinal issues
- Repair of the brain-gut axis
- Positive effects on the central nervous system affecting the peripheral nervous system & pain
- Reduce symptoms of depression
- Protects the heart
- Beneficial effects on stroke, schizophrenia, & spinal cord injuries
- Helps reverse opioid tolerance
- Increase neurotransmission with dopamine, serotonin, Gaba, &opioid receptors to reduce perception of pain
The peptide experts at All U Health have treated many patients with this peptide & have had great success, such as we did when our patients used BPC-157.
Frequently asked questions
- Is Pentadeca Arginate (PDA) a steroid?
- No, PDA is not a steroid. It is a naturally occurring peptide that originates from a protein found in the stomach & has been modified to improve its stability & bioavailability. Steroids are synthetic hormones that can have a number of side effects, including liver damage, heart disease, & mood swings.
- Does Pentadeca Arginate (PDA) interact with any other medications?
- PDA is a peptide that generally does not interact with other medications or substances in a significant way. However, if you are taking any specific medications or have underlying medical conditions, it’s always best to consult with a healthcare professional to ensure there are no potential interactions or adverse effects.
- How long does it take to see results?
- The time it takes to see results with PDA as it depends on the severity of the injury. Some people may notice improvements within a few days to a couple of weeks, while others might take longer. It’s important to be patient & consistent with the use, as its effects may take time to become noticeable.
- How long should PDA be taken?
- It is recommended that the maximum duration is 2 months then taking the same duration off, so 2 months on, 2 months off. This time off allows the body to continue the healing process at a natural pace to ensure long term correction.
- Does PDA affect hormones?
- PDA is not known to directly affect hormones in the body. It primarily works to promote healing and tissue repair, particularly in the gastrointestinal system, muscles, & other tissues.